Preparação de formulações de álcool em gel utilizando agentes espessantes alternativos ao carbopol.

Abstract

At the end of 2019, a new epidemic, triggered by the SARS-CoV-2 virus, emerged in China, making it necessary for more countries to come together to address the health and economic impact of infections. In view of the great demand for these alcohol-based antiseptics, there has been a shortage of raw materials for worldwide production, so this study aimed to develop a gel alcohol formulation using alternative thickening agents to carbopol. The method used was the development of 03 alternatives, in which the compatibility between different gelling agents and reference thickener was confirmed. Organoleptic tests of appearance, color and smell, and physicochemical tests of pH, viscosity and alcohol content were carried out, besides an advanced stability test, aiming to predict possible uncertainties. It was concluded that the best alternative for replacing Carbopol in alcohol gel formulation can be Cellosize, thickener distributed by the company GRANDBOX showed satisfactory results in all analyzed organoleptic and physicochemical criteria, even not reaching the standards determined by ANVISA.